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　　Introduction to oral solid dosage equipment:

　　1 Common tablet production process

　　The production methods of tablets include: compression after granulation (dry and wet granulation) and direct compression, which are suitable for crystalline and powdered materials.

　　2. Tablet pressing process after wet granulation:

　　Raw/Auxiliary Materials → Grinding and Sieving → Mixing → Wet Granulation → Drying → Granulation → Final Blending → Tablet Pressing → Coating → Inner and Outer Packaging.

　　Equipment for each process step in the production of 3 tablets

　　Weighing and batching process → granulation process → tablet pressing process → coating process → inner packaging process

　　The wet mixing granulator is one of the commonly used process equipment in the production of solid dosage forms in the pharmaceutical industry. It is widely applied in the mixing of powders and powders, as well as the granulation of powders with binders, in various industries such as medicine, chemical, and food. The entire machine is controlled by a programmable controller (human-machine interface - optional), ensuring consistent quality through unified processes. It can also be manually operated, facilitating the exploration of process parameters and procedures. Both the mixing paddle and cutting knife adopt frequency control, making it easy to control the particle size. The rotating shaft cavity is sealed with air inflation, eliminating dust adhesion. It features an automatic cleaning function. The conical material chute enables uniform tumbling of materials. The chute bottom is laminated, with a built-in water cooling circulation system, providing better temperature stability than general air cooling systems, thereby improving the quality of particles. The lid automatically lifts, and the discharge port matches the drying equipment. Large models come with escalators for easy operation. Equipped with a paddle lifting system, it is more conducive to cleaning the paddles and the pot body. The discharge port is designed as a circular arc, eliminating dead spaces.

　　Working principle:

　　The granulation process of this machine is completed in the same container through two steps: mixing and granulation. The powdered material is placed in a fixed conical container, where it is agitated by the mixing paddle, causing the material to collide and disperse into a semi-fluid tumbling state, achieving thorough mixing. With the injection of binder, the powder gradually becomes moist, and the shape of the material changes, enhancing the squeezing, rubbing, and kneading effects of the mixing paddle and the cylinder wall on the material, thus forming a moist and uniform soft material. These soft materials are gradually formed into small and uniform wet granules under the high-speed cutting and granulation of the granulation paddle, and finally discharged through the discharge port. The granule size is constrained by factors such as the characteristics of the material, the rotational speed of the granulation knife, and the granulation time.

　　Features:

　　1. The metered spraying of liquid by the atomizer ensures uniform and stable particle composition.

　　2. High production efficiency (each batch only takes a few minutes), good particle fluidity, and high compressibility and fillability.

　　3. Dual-frequency control for optimal granule effect.

　　4. The simple and reliable torque-balanced cover-opening mechanism can be positioned at any angle, making it convenient to use, safe, and reducing labor intensity.

　　5. The touchscreen control interface is intuitive and easy to operate, and the process parameters can be stored.

　　6. The equipment surface is smooth, free of dead spaces, easy to clean, and meets GMP requirements.